Research
Our primary research areas include:
- Mechanobiology and Biomechanics
- Engineered Tissues
- Diagnostics, devices, and instrumentation
- Imaging and Photonics
- Biomaterials/Materials Science
Bioengineer research groups are affiliated with the Harper Cancer Research Institute, the Institute for Precision Health, and other Notre Dame research centers, giving graduate students access to world class facilities and experts in biomedical and engineering research. Research is supported by grants from the NIH, NSF, DOD, American Heart Association, American Cancer Society, and other foundations as well as by industry.
Biomaterials
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Donny Hanjaya-Putra
Biomimetic materials to control stem cell differentiation and morphogenesis. -
Maria Holland
Mechanics of growth in soft tissues; computational modeling of brain growth and development. -
Ryan Roeder
Imaging probes, nanoparticles, scaffolds -
Joshua Shrout
Discernment of bacterial pathogen colonization of implanted biomaterials. -
Matthew Webber
Self-assembly of peptide and protein-based biomaterials through affinity.
Cancer
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Başar Bilgiçer
Development of diagnostics tools for the proper assessment of food and drug allergies. Development of super sensitive protein-biomarker detection sensors for cancer diagnostics. -
Meenal Datta
Tumor microenvironment, cancer immunotherapy, mechano-immunology, drug delivery -
Glen Niebur
Experimental, computational, and in vivo models of bone and bone marrow mechanobiology applied to osteoporosis, cancer metastasis, and metabolic diseases. -
Pinar Zorlutuna
Soft tissue mechanics, bioengineering, tissue engineering, mechanobiology
Computational and Systems Biology
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Tijana Milenkovic
Network science, network mining, computational biology, computational graph theory, algorithms.
Drug Delivery/Therapeutics
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Başar Bilgiçer
Development of targeted nanoparticle drug carriers for various cancers. Engineering of allergic reaction inhibitors. -
H. Chia Chang
Developing low-cost liquid biopsy nanotechnologies for cancer screening and therapy management. -
Donny Hanjaya-Putra
Engineering stem cell for site-specific targeting therapeutics. -
Ryan Roeder
Controlled growth factor delivery from biomaterial scaffolds -
Matthew Webber
Spatiotemporal targeting of molecular therapeutics through tunable supramolecular affinity
Environmental Science
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Robert Nerenberg
Biofilms, especially membrane-biofilm reactors (MBfRs) and membrane biofouling -
Joshua Shrout
Community behavior and biofilm development of bacteria.
Health Robotics and Technology
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Paul Bohn
Use of molecular nanotechnology for chemical analysis -
Danny Chen
Biomedical image processing and analysis, computational biomedicine, medical treatment planning, deep learning methods for biomedical applications. -
Scott Howard
Technology achieving high-resolution 3D microscopy in living tissue. -
Emily Johnson
Parametric modeling and performance-based design of complex medical devices (e.g., heart valves). -
Thomas O'Sullivan
Development of optical spectroscopy and imaging techniques for preclinical and clinical studies. technology for wearable and implantable optical biosensors. -
Ryan Roeder
Nanoparticle imaging probes, contrast-enhanced CT, molecular imaging with spectral CT. -
James Schmiedeler
Biomechanics of human motion, robot- and technology-assisted rehabilitation. -
Bradley Smith
Imaging of cancer and infection; fluorescence guided surgery. -
Patrick Wensing
Robot- and technology-assisted rehabilitation; human-machine interface technologies.
Mechanobiology and Physical Effects on Cells
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Donny Hanjaya-Putra
Mechanical regulation of stem cell differentiation in vascular and lymphatic systems. -
Maria Holland
Mechanics of growth in soft tissues; computational modeling of brain growth and development -
Glen Niebur
Experimental, computational, and in vivo models of bone and bone marrow mechanobiology applied to osteoporosis, cancer metastasis, and metabolic diseases. -
Pinar Zorlutuna
Tissue Engineering, Biorobotics, Stem Cells, Micro/nanofabrication, Organ-on-chip.
Orthopaedics
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Glen Niebur
Experimental, computational, and in vivo models of bone and bone marrow mechanobiology applied to osteoporosis, cancer metastasis, and metabolic diseases. -
Joshua Shrout
Prosthetic joint infections.
Engineered Cells and Tissues
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Donny Hanjaya-Putra
Stem cell for tissue engineering and disease modeling. -
Glen Niebur
Experimental, computational, and in vivo models of bone and bone marrow mechanobiology applied to osteoporosis, cancer metastasis, and metabolic diseases. -
Gregory Timp
Nanobiotechnology; biophysics; single molecule detection; protein nanopore sequencing; secretome detection and transfection; synthetic tissue; cancer metastasis; induced pluripotent stem cells; visualizing live cell physiology with high-resolution using STEM -
Matthew Webber
Injectable and responsive materials for support of therapeutics cell populations and delivery of regenerative signals. -
Jeremiah Zartman
Biological systems; Developmental biology; Growth Control; Regeneration; Systems bioengineering -
Pinar Zorlutuna
Tissue Engineering, Biorobotics, Stem Cells, Micro/nanofabrication, Organ-on-chip.
Rehabilitation and Motor Control
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Edgar Bolívar-Nieto
Biomechanics of human motion, robot- and technology-assisted rehabilitation. -
Margaret Coad
Biomechanics of human motion, robot- and technology-assisted rehabilitation. -
James Schmiedeler
Biomechanics of human motion, robot- and technology-assisted rehabilitation. -
Patrick Wensing
Robot- and technology-assisted rehabilitation; human-machine interface technologies.
Sensors and Diagnostics
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Başar Bilgiçer
Development of diagnostics tools for the proper assessment of food and drug allergies. Development of super sensitive protein-biomarker detection sensors for cancer diagnostics. -
Merlin Bruening
Development of thin films for specific protein capture in porous membranes, ion separations in electrodialysis, and controlled protein digestion prior to analysis with mass spectrometry. -
Hsueh-Chia Chang
Development of low-cost liquid biopsy nanotechnologies for cancer screening and therapy management. -
David Go
Development of microfluidic technologies for cancer screening and diagnostics. Development of ionization sources for mass spectrometry for biochemical analysis. -
Nosang Myung
Development of intelligent sensor systems for precision health including electronic nose and tongue. -
Thomas O’Sullivan
Development of optical spectroscopy and imaging techniques for preclinical and clinical studies. technology for wearable and implantable optical biosensors. -
Joshua Shrout
Development of Screening and assessment of bacterial pathogens for drug susceptibility.